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Comparison of interactions between reovirus disassembly intermediates as well as mutants and β1 integrin show that λ2 is the integrin ligand. Here, we use single-virus force spectroscopy and confocal microscopy to discover a direct interaction between reovirus and β1 integrins. While integrin-binding motifs in the surface-exposed region of reovirus capsid protein λ2 are thought to mediate integrin interaction, evidence for direct β1 integrin-reovirus interactions and knowledge of how integrins function to mediate reovirus entry is lacking. In particular, β1 integrin is required for endocytosis of reovirus virions following junctional adhesion molecule A (JAM-A) binding. After interaction of reovirus attachment protein σ1 with cell-surface carbohydrates and proteinaceous receptors, additional host factors mediate virus internalization. Reovirus infection requires the concerted action of viral and host factors to promote cell entry. Independent Regulation of Reovirus Membrane Penetration and Apoptosis by the μ1 φ DomainĬurrent understanding of reovirus oncolysis mechanisms Current understanding of reovirus oncolysis mechanisms Independent Regulation of Reovirus Membrane Penetration and Apoptosis by the. Isolation of Reovirus T3D Mutants Capable of Infecting Human Tumor Cells Independent of Junction Adhesion Molecule-Aīid Regulates the Pathogenesis of Neurotropic Reovirus Bid Regulates the Pathogenesis of Neurotropic Reovirus Isolation of Reovirus T3D Mutants Capable of Infecting Human Tumor Cells. Neutrophil elastase, an acid-independent serine protease, facilitates reovirus uncoating and infection in U937 promonocyte cells Neutrophil elastase, an acid-independent serine protease, facilitates. Reovirus Preferentially Infects the Basolateral Surface and Is Released from the Apical Surface of Polarized Human Respiratory Epithelial Cells Reovirus Preferentially Infects the Basolateral Surface and Is Released from. Autonomous Reovirus Strain Classification Using Filament-Coupled Antibodies Autonomous Reovirus Strain Classification Using Filament-Coupled Antibodies